Dr. Wartman and FLT3 mutation, On Charlie... | The Leukemia ...

On Charlie Rose Tuesday night was a segment on the New York Times Story by Gina Kolata about Leukemia gene research with Dr. Wartman and Dr DiPersio. The TV segment was basically a follow up to her story recently in the Times.

Dr Wartman is a research scientist/doctor who happened to come down with A.L.L. while he was doing gene research on Leukemia.? On his 3rd relapse they ran out of options so his research team devoted all their time to sequencing his DNA & RNA.? They found the flt3 gene was mutated and over active. I got the impression that this mutant gene is not known to be associated with A.L.L, but is in AML and other cancers.? Long story short, if they had not done the DNA/RNA sequencing they would have never suspected the flt3 gene and he would have probably died.? Fortunately, they found the drug "Sunitinib" which is effective on kidney cancer, was effective on this flt3 gene.? He's been in Remission since last fall.? One of the points the research made was that the driver for his cancer is a gene which could be the same driver for another unrelated cancer,? and without genome research this association may not have been found.

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I find this type of research very fascinating and I just hope more discoveries will come.

Source: http://community.lls.org/thread/16466

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