Fake Craigslist ad for nude photos was 'prank'

3 hrs.

lt was meant as a "prank,"?but it wound up terrifying the victim: A male "friend" placed a Craigslist ad in a woman's name, along with graphic photos of her, inviting men to respond in kind and?send porn photos of themselves to the woman.

The woman, a resident of Chesterfield Township, Michigan, received more than 80 text messages within the first hour the ad was placed online, she told police.

"The person who posted it thought it would be funny, and didn't think it would get that many responses," Detective Sergeant Deron Myers of the Chesterfield Police told msnbc.com.

After the victim contacted police, they got a search warrant for Craigslist?to find out the name of the person who put the ad online. When the victim learned it was a friend of hers, she declined to press charges, Myers said. And the "friend" was appropriately remorseful, he said.

"It got way more attention than he thought" it would, Myers said. In the end,?"All parties just kind of shrugged it off as a tasteless joke."

Not all such incidents work out that way. Last year, Tracy Wilder, of Florida,?started getting knocks on her door, emails and text messages after the wife of Wilder's ex-husband placed a steamy?Craigslist ad in Wilder's name, giving out her phone number and inviting men to come to Wilder's home, with children living there.

The experience was "absolutely appalling,"?Wilder told TODAY's Ann Curry, last summer. (That video interview is below.)

??Via Patch.com?

Check out Technolog, Gadgetbox, Digital Life and In-Game on Facebook,?and on Twitter, follow Suzanne Choney.

Source: http://www.technolog.msnbc.msn.com/technology/technolog/fake-craigslist-ad-naked-photos-brings-results-remorse-suspect-858553

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Phillies trade Thome to Orioles for minor leaguers

BALTIMORE (AP) ? Slugger Jim Thome is headed to the Baltimore Orioles, whose struggling offense is in dire need of some punch.

Thome was traded from the Philadelphia Phillies on Saturday for two young minor leaguers ? right-hander Kyle Simon and catcher Gabriel Lino.

The 41-year-old Thome is a five-time All-Star. His 609 homers are tied with Sammy Sosa for seventh place on the career list, and his 1,689 RBIs over a 22-year career are 25th all-time.

Thome will move right into the designated hitter role with the Orioles, who have been a surprising contender in the AL East. Out for much of the season with a lower back strain, Thome didn't figure to see much time in the field for the slumping Phillies. He also had struggled as a pinch hitter.

"There's a part of me that's happy to go and get a chance to play a little bit. Baltimore is having a nice year and it will be exciting to go over there and try to help those guys win and get some at-bats. I'm excited about that, for sure," Thome said.

"There's always emotions when you're traded because you have so much respect for the Phillies organization," he said.

In 30 games for the Phillies this season, Thome hit .242 with five home runs and 15 RBIs. He missed more than a month with the back problem and the Phillies didn't want to risk having him get hurt again.

"I think the disappointing thing for me is that I wasn't able to play as much first base as I thought," he said.

As a DH, Thome can purely focus on hitting.

"We felt Thome's presence and our need on the major league team were worth the value we have to give up in a trade," said Dan Duquette, the Orioles executive vice president of baseball operations. "We like both the young players. They're both in A ball. We needed some help to bolster our lineup."

Thome appears to be the perfect fit.

"Jim Thome's a real pro, and he specializes in hitting home runs and getting on base," Duquette said. "He's done that consistently his whole career. Beyond that, he's a terrific teammate and a steady presence. He's a veteran, he's been around the league. He's been in the pennant race and he's been in the playoffs. We like all those things that he brings to our team.

"I think he gives us a little bit more depth to our lineup with the injuries we've had, the left-handed hitters in our lineup. I think his presence in the lineup will make the opposing pitchers work harder. Because he gets on base and hits home runs and can hit the ball out of any part of this ballpark, we think he'll be an asset to the team."

The Orioles got a good look at Thome earlier this month when he went 6 for 13 with four RBIs in a three-game series at Camden Yards. He also got his first home run and RBI of the year that weekend.

Thome has done quite well in Baltimore over the years. In 67 career games at Camden Yards, he's hit 18 home runs ? one every 13.6 at-bats ? with 45 RBIs. Of the 65 homers to land on distant Eutaw Street in two decades, Thome has launched two of them.

"I think everybody in baseball has been a fan of Jim, the way he carries himself and conducts himself," Orioles manager Buck Showalter said "The most important thing is, this is a guy that can help us with some things between the lines and outside the lines. If you have an opportunity to add him to the mix, you always want to try to do it."

Phillies manager Charlie Manuel told him about the trade after a 3-2 loss at Miami in which Thome didn't play. At the time, the Orioles were still playing in an 11-5 loss to Cleveland.

"I think it's going to give Jim a chance to get more at-bats. And at the end of this year it will give him a chance to see where he's at and what he wants to do," Manuel said.

"Yes, it's difficult for me to see him go. But at the same time, you look at it from the aspect of what he can do. If he sits here on the bench, it's hard for him to keep his timing," he said.

Baltimore will assume the rest of the one-year, $1.25 million contract he signed with Philadelphia in November 2011.

The Orioles have scored more than three runs in two of their last 12 games and is averaging six hits over the last 14 contests. They have been struggling to produce with runners in scoring position, going 11 for 82 in that situation over a 14-game span.

In addition, they were operating without injured DH Nick Johnson and outfielder Nolan Reimold.

Baltimore will be Thome's sixth team. He previously played for Cleveland, Minnesota, the Chicago White Sox, Los Angeles Dodgers and Phillies.

"I think it's bittersweet, to be honest. Jim's a great teammate and I think we're all sorry to see him go but we're all excited that he'll have the opportunity to get at-bats daily. He can still do a lot of damage," Phillies second baseman Chase Utley said.

Echoed Phillies pitcher Cole Hamels: "He's one of the best guys in baseball and probably one of the most positive influences you could ever have just because he's been around the game."

"He's going to go to the Hall of Fame. It's not every day you get to play with a Hall of Famer," he said.

Marlins manager Ozzie Guillen had Thome on the team with the White Sox.

"The Orioles just picked up a great baseball player, an unbelievable human being, and a great teammate," Guillen said. "I think that's better for him, get more at-bats, play in the American League where he can DH. It will also help the people in the clubhouse because of how good he is."

Simon, 21, was 2-8, 3.96 ERA in 14 starts for Class A Frederick.

Lino, 19, hit .218 four homers and 18 RBIs for Class A Delmarva.

Source: http://news.yahoo.com/phillies-trade-thome-orioles-minor-leaguers-225956629--mlb.html

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Scientists develop alternative to gene therapy

ScienceDaily (July 1, 2012) ? Scientists at The Scripps Research Institute have discovered a surprisingly simple and safe method to disrupt specific genes within cells. The scientists highlighted the medical potential of the new technique by demonstrating its use as a safer alternative to an experimental gene therapy against HIV infection.

"We showed that we can modify the genomes of cells without the troubles that have long been linked to traditional gene therapy techniques," said the study's senior author Carlos F. Barbas III, who is the Janet and Keith Kellogg II Professor of Molecular Biology and Chemistry at The Scripps Research Institute.

The new technique, reported in Nature Methods on July 1, 2012, employs zinc finger nuclease (ZFN) proteins, which can bind and cut DNA at precisely defined locations in the genome. ZFNs are coming into widespread use in scientific experiments and potential disease treatments, but typically are delivered into cells using potentially risky gene therapy methods.

The Scripps Research scientists simply added ZFN proteins directly to cells in a lab dish and found that the proteins crossed into the cells and performed their gene-cutting functions with high efficiency and minimal collateral damage.

"This work removes a major bottleneck in the efficient use of ZFN proteins as a gene therapy tool in humans," said Michael K. Reddy, who oversees transcription mechanism grants at the National Institutes of Health's (NIH) National Institute of General Medical Sciences, which helped fund the work, along with an NIH Director's Pioneer Award.

Questioning Assumptions

ZFNs, invented in the mid-1990s, are artificial constructs made of two types of protein: a "zinc-finger" structure that can be designed to bind to a specific short DNA sequence, and a nuclease enzyme that will cut DNA at that binding site in a way that cells can't repair easily. The original technology to make designer zinc finger proteins that are used to direct nucleases to their target genes was first invented by Barbas in the early 1990s.

Scientists had assumed that ZFN proteins cannot cross cell membranes, so the standard ZFN delivery method has been a gene-therapy technique employing a relatively harmless virus to carry a designer ZFN gene into cells. Once inside, the ZFN gene starts producing ZFN proteins, which seek and destroy their target gene within the cellular DNA.

One risk of the gene-therapy approach is that viral DNA -- even if the virus is not a retrovirus -- may end up being incorporated randomly into cellular DNA, disrupting a valuable gene such as a tumor-suppressor gene. Another risk with this delivery method is that ZFN genes will end up producing too many ZFN proteins, resulting in a high number of "off-target" DNA cuts. "The viral delivery approach involves a lot of off-target damage," said Barbas.

In the new study, Barbas and his colleagues set out to find a safer ZFN delivery method that didn't involve the introduction of viruses or other genetic material into cells. They experimented initially with ZFN proteins that carry extra protein segments to help them penetrate cell membranes, but found these modified ZFNs hard to produce in useful quantities. Eventually, the scientists recognized that the zinc-finger segments of ordinary ZFNs have properties that might enable the proteins to get through cell membranes on their own.

"We tried working with unmodified ZFNs, and lo and behold, they were easy to produce and entered cells quite efficiently," Barbas said.

New Strategy Against HIV

Next, the team showed how the new technique could be used in a ZFN-based strategy against HIV infection.

The AIDS-causing retrovirus normally infects T cells via a T cell surface receptor called CCR5, and removing this receptor makes T cells highly resistant to HIV infection. In 2006, an HIV patient in Berlin lost all signs of infection soon after receiving a bone marrow transplant to treat his leukemia from a donor with a CCR5 gene variant that results in low expression of the receptor. Disrupting the CCR5 gene in T cells with a ZFN-based therapy might be able to reproduce this dramatic effect.

"The idea is to protect some of the patient's T cells from HIV, so that the immune system remains strong enough ultimately to wipe out the infection," said Barbas.

A gene therapy that uses ZFNs to disrupt CCR5 genes in T cells and reinfuses the modified T cells into patients is currently in clinical trials. Barbas and his team showed that they could achieve the same effect with their simpler ZFN-delivery method. They added ZFN proteins directly to human T cells in a culture dish and found that within hours, a significant fraction of the ZFN-treated cells showed sharp reductions in CCR5 gene activity.

After several applications of ZFNs, aided by a special cooling method that improves the ability of the proteins to get across cell membranes, the scientists were able to inactivate CCR5 genes with an efficiency approximating that of the gene therapy-based approach, Barbas said.

The new approach also appeared to be safer. A DNA-based method the team used for comparison or the viral-based methods reported in the literature by others ended up producing ZFNs for up to several days, causing a significant amount of off-target DNA damage. But the directly delivered ZFN proteins remained intact within cells for only a few hours, causing minimal off-target damage.

"At some off-target locations where the gene therapy approach frequently causes damage, we saw no damage at all from this new technique," said Barbas.

Hope for 'Tiny Factories' of Health

The team tested its direct ZFN-delivery technique with a variety of other cell types and found that it works with particularly high efficiency in human skin "fibroblast" cells. Researchers now are working on advanced therapies in which they harvest such fibroblasts from patients and reprogram the cells' gene-expression patterns so that they effectively become stem cells. These induced stem cells can then be modified using ZFNs and other genome-editing techniques. When reinfused into a patient, they can produce millions of therapeutic progeny cells over long periods.

Such techniques may one day be used to treat a vast array of diseases. Barbas, who has been developing anti-CCR5 strategies for more than a decade, wants to start with a ZFN-based therapy that disrupts the CCR5 gene in hematopoietic stem cells. These blood-cell-making stem cells, reinfused into an HIV patient, would become tiny factories for producing HIV-resistant T cells.

"Even a small number of stem cells that carry this HIV-resistance feature could end up completely replacing a patient's original and vulnerable T cell population," he said.

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The above story is reprinted from materials provided by Scripps Research Institute, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/07/120701191613.htm

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The Nexus Q Is Also a Magic 8-Ball [Android]

Google's Nexus Q is many thing to many people. A miniature Death Star, an alien being, necessary but overwrought or, umm, a media streamer. It also has an extra, hidden function: it works as a magic 8-ball. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/vuCq1T7J6gI/the-nexus-q-is-also-a-magic-8+ball

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Social Media Is Making Today?s Girls Actually Say What They Mean

4431.censoredlatatf.jpg-550x0The stereotype is that women generally enjoy talking and communicating more than men. But they haven't always been known to be the most straightforward with the nitty-gritty of what they really think and feel -- females are sometimes wired to be a people-pleasing bunch. But according to a recent article in the UK's Daily Mail, some language experts say that today's girls are becoming more blunt and direct, thanks to the rise of technologies such as texting and social media.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/hkLbf2y5ifQ/

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Panasonic's Eluga V for NTT DoCoMo swings past the FCC

Panasonic Eluga V

Panasonic's Eluga V smartphone arrived at NTT DoCoMo back in May and now the company has dropped one of its handsets off at the FCC's underground bunker. The Ice Cream Sandwich-running phone has a 4.6-inch, 1280 x 720 display, wireless charging, the same water and dust proofing that we saw in its two brothers, HSPA, Bluetooth 3.0 and 802.11 b/g/n WiFi. Don't let the news of governmental approval get your hopes up for a stateside launch however, this one's just to ensure that tourists won't have the handset seized as soon as they reach customs.

Panasonic's Eluga V for NTT DoCoMo swings past the FCC originally appeared on Engadget on Sat, 30 Jun 2012 13:14:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/06/30/eluga-v-fcc/

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One killed in Yemen as army pursues militants

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Source: http://news.yahoo.com/one-killed-yemen-army-pursues-militants-081535191.html

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Sanjay Sanghoee: Is Health Care Ruling Part of a Conservative Master-Plan?

The Supreme Court's upholding of the Patient Protection and Affordable Care Act is a victory for President Obama, but one with a big problem attached to it. After all, there is a deadly tripwire concealed inside the court's seemingly benign ruling, and that is the court's declaration that the individual mandate provision, the heart of Obamacare, is legally valid because it is a de facto "tax."

By labeling the mandate a tax, the Supreme Court has given the Republicans powerful ammunition for the Presidential campaign. From now till November, it is a safe bet that Mitt Romney will take every opportunity to demonize the healthcare law as a vehicle for more taxation, and in the tough economic climate of today, his argument might hold some power. Scaring voters with the specter of new taxes may not be novel, but it is tried and tested.

So now we have to ask, what exactly did the Supreme Court do here? On the surface, they acted in a non-partisan manner to deliver real justice, but reading between the lines, it seems more as if Justice John Roberts deliberately sandbagged President Obama. Had the Supreme Court ruled against the healthcare law, or even just the mandate, the public's respect for the court would have declined dramatically, and Justice Roberts knew that. As an alternative, it appears as if he hatched a strikingly clever plan: uphold the law but interpret it in such a way as to give the Republicans a real chance to rally support against Obamacare and hopefully repeal it in the future. Not only that, but the ruling also limits Congress' authority to regulate commerce and weakens its power over the states.

One of Justice Roberts' statements in the opinion, which he wrote himself, drives his personal prejudice home very clearly: "It Is Not Our Job to Protect the People From the Consequences of Their Political Choices." It does not take a political analyst to decipher the ominous implication in that statement -- Justice Roberts thinks that the American people made the wrong choice by electing Obama and then letting him pass the healthcare law, but that it's just not the Supreme Court's role to do anything about it. Talk about passive aggressive.

The current Supreme Court may not be malicious but neither is it entirely impartial in its rulings, or apolitical. From Citizens United to immigration (by upholding the "show your papers" provision of the Arizona law) and now healthcare, the conservative wing of the court has repeatedly shown its preference for ideology over law.

Since the healthcare ruling, the news has been full of commentary about how Justice Roberts preserved the integrity of the court by upholding the president's signature law, but the truth is he did nothing of the sort. What he actually did was play a masterful stroke of chess that protects him and the other conservative Justices from public ridicule (save from a few right-wing extremists) while still playing ball with the Republicans. Justice Roberts may be conservative in his judicial thinking but he is also smart enough to know that striking down a populist law that will provide relief for millions of middle class and poor Americans is really bad politics.

Given all this, we should stop idolizing Justice Roberts' seemingly noble gesture and recognize it for what it really is -- a political gambit to help Romney win the elections in November and to push the United States towards the conservative agenda incognito. Only time will tell what this all leads to, but there is a very real chance that the vote that Justice Roberts cast in favor of the healthcare law was his most conservative one yet.

?

?

?

Follow Sanjay Sanghoee on Twitter: www.twitter.com/sanghoee

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Source: http://www.huffingtonpost.com/sanjay-sanghoee/was-john-roberts-healthca_b_1639851.html

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Octomom and Frankie Grageda Go on a Date!!!!!


Octomom Nadya Suleman and new boyfriend Frankie Grageda went on a date this week. Stunning and breaking news right there, we know. Breathe.

Who knows how you arrange a babysitter when you have 14 children and a house in foreclosure, but lo and behold, Octomom apparently pulled it off.

Gotta make time for yourself and your love life, right?!

Octomom and Frankie Grageda

Octo began dating Frankie G, a 23-year-old bodybuilder, two months ago.

That's a decent chunk of time, but the pair had not been able to go on their first real date without the brood until this week, when Frankie stepped up to the plate.

He reportedly got a friend to watch the kids so he could take her to the beach in Santa Monica! There, she reenacted these scenes from the Octomom porn movie.

Just kidding ... but it wouldn't have surprised us.

The two worked out together on the beach, with Frankie Grageda helping her get in shape for her stripper gig at The Playhouse in Hollywood, Fla., on July 13.

Who said true romance was dead?

[Photo: TMZ]

Source: http://www.thehollywoodgossip.com/2012/06/octomom-and-frankie-grageda-go-on-a-date/

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