Source: http://rss.slashdot.org/~r/Slashdot/slashdot/~3/CJrpR3uBH0M/android-41-jelly-bean-review
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Rep. Joe Walsh (R-Ill.), locked in an election battle with Democrat Tammy Duckworth -- who lost both legs and partial use of her arm in Iraq -- said she talks too much about her military service, something "true heroes" don't do.
Walsh's comment -- especially coming before the Fourth of July -- touched off a firestorm on Tuesday that spread beyond the 8th Congressional District in the northwest suburbs, where the two are running.
"Now I'm running against a woman who, I mean, my God, that's all she talks about. Our true heroes, the men and women who served us, it's the last thing in the world they talk about. That's why we're so indebted and in awe of what they have done," Walsh said.
Duckworth Campaign Manager Kaitlin Fahey, in a statement, said "Walsh's comments insult those who sacrificed to make this country free. Tammy is proud of her over 20 years of service with the Army and her family's legacy of fighting for this country. We can't recognize our servicemen and women enough and ask that we keep them in our thoughts during this holiday week."
Walsh issued a statement in reply on Tuesday -- and did not back down on the point that he thinks Duckworth talks too much about her military service.
"Of course Tammy Duckworth is a hero," Walsh said. "I have called her a hero hundreds of times in the past four months. Just like every man and woman who has worn the uniform, her service demands -- demands -- our utmost respect. That's why I recognize our veterans at the beginning of every one of my public town halls. However, unlike most veterans I have had the honor to meet since my election to Congress, who rarely if ever talk about their service or the combat they've seen, that is darn near all of what Tammy Duckworth talks about."
Walsh is a freshman lawmaker known for his provocative remarks. He talked about Duckworth on Sunday at a town hall meeting in Elk Grove he hosted to discuss ObamaCare in the wake of the Supreme Court decision to uphold the Affordable Care Act.
The Duckworth campaign told me Tuesday Walsh was videotaped by a Duckworth intern at the town hall -- with the clip of him posted by the campaign on YouTube on Monday.
By Tuesday, Duckworth allies -- including Sen. John Kerry (D-Mass.) -- a Vietnam War hero who found his record disparaged during his 2004 presidential bid -- seized on Walsh's remarks to rally to her defense.
"Unbelievable! Tammy Duckworth Swiftboated," said a fund-raising e-mail from Kerry -- a reference to his 2004 takedown by an anti-Kerry group called Swiftboat Veterans for Truth who, not liking his politics, attacked -- successfully -- his heroism.
Duckworth lost both legs and shattered an arm when her helicopter was shot down in Iraq in November 2004. She ran for Congress in 2006, was defeated and went on to run the Illinois Department of Veterans' Affairs, and to become an Assistant Secretary of Public and Intergovernmental Affairs for the Department of Veterans Affairs. She is also a lieutenant colonel in the Illinois Army National Guard.
Walsh set up his remarks about Duckworth by praising Sen. John McCain (R-Ariz.) for what he saw as his reluctance to talk about his experiences as a war hero during his 2008 presidential campaign. However, McCain wrote a book, Faith of My Fathers, about his experiences as a prisoner of war in Vietnam--and used his military career and POW years to help define himself as he pursued a political career.
Source: http://blogs.suntimes.com/sweet/2012/07/joe_walsh_says_tammy_duckworth.html
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[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]
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Source: http://news.yahoo.com/sudan-signs-deals-oil-companies-9-blocks-111135685--finance.html
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Investing for retirement is something every person should think about the minute they start earning money. Like it or not, there will come a time when working is no longer an option, thus making it necessary for an individual to survive without a constant influx of funds. This can be done by opting for various investment choices that will provide them with cash even without having to work.
That being said, following are some of the methods of investing for retirement.
Investing for Retirement ? IRA
An IRA or Individual Retirement Account is one of the most common ways to invest for retirement. What is great about this method is that the money isn?t taxed until the individual decides to withdraw the funds placed in the account. Typically, individuals can open up an IRA at a bank and place a specific amount on a timely basis.
This is usually divided between bonds and stocks, ensuring a specific amount of safety for the individual. The IRA also allows the investment of precious metals in the account for diversification. A different type of IRA called Roth has also been introduced in the market since 1998. With this type, individuals can grow their investment without the burden of taxes. Typically, an IRA is used by people who have no 401K or those that are privately employed.Investing for Retirement - 401K
The only difference with choosing investing for retirement between a 401K and an IRA is the fact that the former is offered by an employer. Typically, 401K investment plans are enjoyed by employees through their employers. Hence, the process usually means that the fund are directly removed from the person?s salary and credited into their account.
The amount is also tax deductible and is often invested in various instruments that are left at the hands of the employer. Hence, individuals who are settled in a large company with a 401K should already be well off without investing further outside work. Like IRA, a 401K also has precious metal options but this should be discussed with the employer first.Investing for Retirement - Bank Account
Some people maintain a retirement fund separate from their main account. This is usually considered an ?extra precaution? just in case the IRA or 401K doesn?t perform as well as expected. Hence, individuals who are saving up cash in banks for retirement should make sure that they either have an IRA or a 401K. In some cases, it is even possible for them to have all three. The main problem with this system is that the funds do not really generate an acceptable rate of income.
Investing for Retirement - Physical Items
Other people choose to invest in physical items such as jewelry, paintings, memorabilia or even collector coins. For example, a painting done by Van Gogh would definitely fetch a handsome price when resold to a museum or a private collector. Depending on the current market, the painting could significantly increase in value, allowing individuals to earn a decent amount from the painting. Typically, investing for retirement on physical items is done not only for the cash opportunity but also for the passion one has for the item.
Of course, those aren?t the only methods of investing for retirement. Ideally, individuals should try to save as much as possible and diversify they investments to ensure financial comfort during their retirement years.
Source: http://retirement.ezinemark.com/top-4-ways-of-investing-for-retirement-7d37832a6f87.html
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One of cancer's most frightening characteristics is its ability to return after treatment. In the case of many forms of cancer, including the skin cancer known as melanoma, tailored drugs can eradicate cancer cells in the lab, but often produce only partial, temporary responses in patients. One of the burning questions in the field of cancer research has been and remains: how does cancer evade drug treatment?
New research by a team from the Broad Institute, Dana-Farber Cancer Institute, and Massachusetts General Hospital suggests that some of the answers to this question do not lie in cancer cells themselves. To find the answers, scientists are looking beyond tumor cells, studying the interplay between cancer cells and their healthy counterparts. The research team has found that normal cells that reside within the tumor, part of the tumor microenvironment, may supply factors that help cancer cells grow and survive despite the presence of anti-cancer drugs. These findings appear online this week in a paper published in Nature.
"Historically, researchers would go to great lengths to pluck out tumor cells from a sample and discard the rest of the tissue," said senior author Todd Golub director of the Broad's Cancer Program and Charles A. Dana Investigator in Human Cancer Genetics at the Dana-Farber Cancer Institute. Golub is also a professor at Harvard Medical School and an investigator at Howard Hughes Medical Institute. "But what we're finding now is that those non-tumor cells that make up the microenvironment may be an important source of drug resistance."
To investigate how the tumor microenvironment may contribute to drug resistance, the researchers designed experiments in which cancer cells were grown in the same wells (miniscule test tubes no larger than a pencil eraser) along with normal cells. These co-cultured cells were then treated with anti-cancer drugs. When grown alone, such cancer cells died in the presence of many of these targeted agents, but when grown together with normal cells, cancer cells developed resistance to more than half of the 23 agents tested.
These observations reflect what clinicians often see in patients with cancers such as melanoma. In the case of melanoma, targeted therapies have been developed against a specific, common mutation in a gene known as BRAF. While some patients' tumors show an overwhelming response to BRAF inhibitors and seem to disappear, other patients' tumors only respond by slightly decreasing in size. The failure to shrink tumors at the outset suggests that those tumors possess some level of innate resistance ? the ability to evade drugs from the beginning of treatment.
"Even though recent advanced in targeted therapy have caused tremendous excitement in melanoma, the fact remains that drug resistance eventually develops in nearly all metastatic melanomas treated with RAF inhibitors, and in some cases is present at the outset of treatment," said Levi A. Garraway, a senior associate member of the Broad Institute, an associate professor at Dana-Farber Cancer Institute and Harvard Medical School. "There are many different types of mechanisms that tumors may hijack to circumvent the effects of therapy?no single experimental approach can capture all of these potential mechanisms. Thus, the application of complementary approaches can offer considerable synergy in terms of discovering the full spectrum of clinically relevant resistance mechanisms."
Scientists have uncovered resistance mechanisms that cancer cells develop over time ? genetic changes in specific genes that may give cancer the ability to overcome the effects of a drug with time ? but these acquired resistance mechanisms do not explain the innate resistance seen in many tumors.
"We can take cancer cells out of a melanoma patient, put them on a dish, and most times they will turn out to be extremely sensitive to the targeted agents, but that's not what we see in patients," said Ravid Straussman, a postdoctoral fellow at the Broad Institute and first author of the Nature paper. "Why do we get just a partial response in most patients? We set out to dissect this question, and the next logical step was to think beyond cancer cells."
After completing systematic, high-throughput screens of more than 40 cancer cell lines, the researchers chose to focus on melanoma, looking at whether factors normal cells secrete help cancer cells resist treatment. They measured more than 500 secreted factors and found that the factor most closely linked to BRAF inhibitor drug resistance was hepatocyte growth factor (HGF). HGF interacts with the MET receptor, abnormal activation of which has been tied to tumor growth in previous studies but never to drug resistance in melanoma.
In addition to studying cells in the lab, the research team sought to replicate their findings in samples from cancer patients. Keith Flaherty, director of developmental therapeutics at Massachusetts General Hospital Cancer Center and an associate professor at Harvard Medical School, and his lab provided 34 patient samples for study. The team measured levels of HGF in these samples and saw a relationship between how much HGF was present and the amount of tumor shrinkage patients experienced. For example, tumors in patients with high levels of HGF shrank less than those in patients with low HGF levels.
"To try to explore in patient samples what factors in the microenvironment are not only present but functionally important in drug resistance would have been largely impossible. Coming up with candidates in the lab and then exploring relevance in humans in a targeted way is the only tractable approach," said Flaherty. "By taking this high-throughput screening, hypothesis-generating approach, we could then follow up by looking at patient samples. In a case like melanoma, where you already have a targeted therapy available, it puts you on good footing to narrow in on specific factors that may be at play in drug resistance."
Several HGF/MET inhibitors are in clinical development or are FDA-approved for other indications, making clinical trials combining these inhibitors with BRAF inhibitors feasible in the future. In addition, researchers could follow the same approach taken by the team to screen other drugs currently in development, identifying mechanisms of resistance and ways to counter them even before treatment begins.
"Drug resistance should no longer surprise us," said Golub. "We're thinking about how to do this ? how to systematically dissect resistance ? much earlier in the drug development process so that by the time a new drug enters the clinic, we have a good sense of what the likely mechanisms of resistance will be and have a strategy to combat them."
###
Broad Institute of MIT and Harvard: http://www.broad.mit.edu
Thanks to Broad Institute of MIT and Harvard for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Source: http://www.labspaces.net/121476/Tumor_microenvironment_helps_skin_cancer_cells_resist_drug_treatment
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By John Cole July 4th, 2012
Idiot:
GOP congressional candidate Chris Collins knows health care is expensive these days, but he argues it?s for good reason: People are no longer dying from deadly forms of cancer.?People now don?t die from prostate cancer, breast cancer and some of the other things,? he told The Batavian in an interview that was flagged Tuesday by City & State NY. Collins was discussing his desire to repeal Obamacare.
So I guess we can stop racing for the cure.
Source: http://www.balloon-juice.com/2012/07/04/congratulations-we-cured-cancer/
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ZipList, the shopping list startup nabbed by?Cond? Nast in April for a reported $14 million, has just added a nifty little tool that makes the "inspirational" imagery found on Pinterest a bit more practical. If you cook and you like pinning stuff, then you'll like this,too. The company has introduced a web browser button that, when clicked, adds the ingredients from a recipe on Pinterest to your current shopping list, which you can view on your phone while at the store. OK, that's kind of handy.Source: http://feedproxy.google.com/~r/Techcrunch/~3/3DZWWykZzRo/
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This week will be remembered as a volatile one if you're a MeeGo fan. Just hours after Nokia posted the PR 1.3 update for N9 owners, the company's MeeGo development lead Sotiris Makyrgiannis and other team members have confirmed that they're leaving for greener pastures. The split appears to be an amicable one, with the crew largely going to CloudBerryTec to write mobile apps (including for MeeGo) and consult on software even as they share fond memories. What's left is a lot of doubt over the fate of the swipe-driven OS itself. Nokia promised years of support for the OS as a side project following the big leap to Windows Phone, but it also hadn't mentioned the possibility of important staff departures, either. We've reached out to the company for a fuller answer -- if it turns out that MeeGo development is winding down, the staff shift could be the end to completely in-house OS creation at a company that was once defined by its custom platforms.
Key MeeGo team members leave Nokia, N9 owners swipe away a few tears originally appeared on Engadget on Wed, 04 Jul 2012 16:13:00 EDT. Please see our terms for use of feeds.
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